Article
[Genetic polymorphism of XRCC1 associated with susceptibility of chromosomal damage in workers exposed by 1,3-butadiene].
Wei sheng yan jiu = Journal of hygiene research - 1 Nov 2010
Wang Qi, Tan Hongshan, Wang Aihong, Feng Nannan, Ye Yunjie, Feng Xiaoqing, Xia Zhaolin
Abstract excerpt
OBJECTIVE: To explore the relationship between genetic polymorphism of XRCC1 194, 280, 399 and susceptibility of chromosomal damage induced by 1,3-butadiene (BD). METHODS: 138 workers occupationally exposed to BD and 41 normal individuals were involved. Cytokinesis-block micronucleus (CB-MN) assay was used to detect chromosome damage in peripheral lymphocyte. PCR-RFLP technique was applied to detect polymorphisms...
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