Article
New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2.
European journal of cell biology - 1 Jul 2010
Fath Thomas, Agnes Chan Yee-Ka, Vrhovski Bernadette, Clarke Hamish, Curthoys Nikki, Hook Jeff, Lemckert Frances, Schevzov Galina, Tam Patrick, Watson Catherine M, Khoo Poh-Lynn, Gunning Peter
Abstract excerpt
Previous studies have shown that the overexpression of tropomyosins leads to isoform-specific alterations in the morphology of subcellular compartments in neuronal cells. Here we have examined the role of the most abundant set of isoforms from the gamma-Tm gene by knocking out the alternatively spliced C-terminal exon 9d. Despite the widespread location of exon 9d-containing isoforms, mice were healthy and...
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