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Article

A recombination hotspot in a schizophrenia-associated region of GABRB2.

PloS one - 8 Mar 2010

Ng Siu-Kin, Lo Wing-Sze, Pun Frank W, Zhao Cunyou, Yu Zhiliang, Chen Jianhuan, Tong Ka-Lok, Xu Zhiwen, Tsang Shui-Ying, Yang Qiang, Yu Weichuan, Nimgaonkar Vishwajit, Stöber Gerald, Harano Mutsuo, Xue Hong

Abstract excerpt

BACKGROUND: Schizophrenia is a major disorder with complex genetic mechanisms. Earlier, population genetic studies revealed the occurrence of strong positive selection in the GABRB2 gene encoding the beta(2) subunit of GABA(A) receptors, within a segment of 3,551 bp harboring twenty-nine single nucleotide polymorphisms (SNPs) and containing schizophrenia-associated SNPs and haplotypes. METHODOLOGY/PRINCIPAL...

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Identifiers

PMID: 20221451
DOI: 10.1371/journal.pone.0009547
PMCID: PMC2833194

Genes

GABRB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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