Article
Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression.
PloS one - 8 Mar 2010
Galmbacher Katharina, Heisig Martin, Hotz Christian, Wischhusen Joerg, Galmiche Antoine, Bergmann Birgit, Gentschev Ivaylo, Goebel Werner, Rapp Ulf R, Fensterle Joachim
Abstract excerpt
A tumor promoting role of macrophages has been described for a transgenic murine breast cancer model. In this model tumor-associated macrophages (TAMs) represent a major component of the leukocytic infiltrate and are associated with tumor progression. Shigella flexneri is a bacterial pathogen known to specificly induce apotosis in macrophages. To evaluate whether Shigella-induced removal of macrophages may be...
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