Article
Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis.
Osteoarthritis and cartilage - 1 Jun 2010
Vargiolu M, Silvestri T, Bonora E, Dolzani P, Pulsatelli L, Addimanda O, Mancarella L, Punzi L, Fioravanti A, Facchini A, Romeo G, Meliconi R
Abstract excerpt
OBJECTIVE: IL-13/IL-4/IL-4R system has strong chondroprotective activity. We investigated polymorphisms in these genes as potential hand osteoarthritis (OA) susceptibility loci by performing a case-control association study. METHODS: Eighteen common single nucleotide polymorphisms (SNPs) (nine in IL-4R, five in IL-4 and four in IL-13) were genotyped in 403 patients (380 females) with hand OA and 322 healthy...
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