Article
Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-C.
Journal of muscle research and cell motility - 1 Dec 2009
Shaffer Justin F, Harris Samantha P
Abstract excerpt
Cardiac myosin binding protein-C (cMyBP-C) is an accessory protein found in the A-bands of vertebrate sarcomeres and mutations in the cMyBP-C gene are a leading cause of familial hypertrophic cardiomyopathy. The regulatory functions of cMyBP-C have been attributed to the N-terminus of the protein, which is composed of tandem immunoglobulin (Ig)-like domains (C0, C1, and C2), a region rich in proline and alanine...
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