Article
Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2020
Vasunilashorn Sarinnapha M, Ngo Long H, Inouye Sharon K, Fong Tamara G, Jones Richard N, Dillon Simon T, Libermann Towia A, O'Connor Margaret, Arnold Steven E, Xie Zhongcong, Marcantonio Edward R
Abstract excerpt
INTRODUCTION: Apolipoprotein E (APOE) status may modify the risk of postoperative delirium conferred by inflammation. METHODS: We tested whether APOE modifies the established association between C-reactive protein (CRP) and delirium incidence, severity, and duration in 553 noncardiac surgical patients aged 70 and older. High postoperative plasma CRP (≥234.12 mg/L) was defined by the highest sample-based quartile....
Topics
- Aged
- Aged, 80 and over
- Alleles
- Apolipoprotein E4
- Apolipoproteins E
- C-Reactive Protein
- Delirium
- Epistasis, Genetic
- Female
- Genotype
- Humans
- Postoperative Complications