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Article

A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy.

Pharmacogenetics and genomics - 1 Apr 2010

Kim Won-Joo, Lee Ji Hyun, Yi Jihyun, Cho Yang-Je, Heo Kyoung, Lee Sung Hee, Kim So Won, Kim Myeong-Kyu, Kim Kyung Hwan, In Lee Byung, Lee Min Goo

Abstract excerpt

OBJECTIVES: Multidrug resistance protein 2 (MRP2, ABCC2) is involved in the transport of antiepileptic drugs and is upregulated in the brain tissues of patients with epilepsy. Therefore, genetic variations in the MRP2 gene may affect individual drug responses to the antiepileptic agent carbamazep...

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Source

Identifiers

PMID: 20216337
DOI: 10.1097/FPC.0b013e328338073a

Genes

ABCC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20216337-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy.PMID 20216337Read ↗

The effects of ABCC2 G1249A polymorphism on the risk of resistance to antiepileptic drugs: a meta-analysis of the literature.Semantic proximity Read ↗

The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs: A meta-analysis.Semantic proximity Read ↗

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Lack of association between polymorphism in ABCC2 gene and response to antiepileptic drug treatment in Croatian patients with epilepsy.Semantic proximity Read ↗

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The recessive model of MRP2 G1249A polymorphism decrease the risk of drug-resistant in Asian Epilepsy: a systematic review and meta-analysis.Semantic proximity Read ↗

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Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital.Semantic proximity Read ↗

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