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Article

Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases

1 Oct 2002

Abstract excerpt

Werner syndrome is a human premature aging disorder displaying cellular defects associated with telomere maintenance including genomic instability, premature senescence, and accelerated telomere erosion. The yeast homologue of the Werner protein (WRN), Sgs1, is required for recombination-mediated lengthening of telomeres in telomerase-deficient cells. In human cells, we report that WRN co-localizes and physically...

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Share to DNA Repair Mechanisms
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Identifiers

PMID: 12181313
DOI: 10.1074/jbc.m205396200

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Related research

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Research trail→

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Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome HelicasesPMID 12181313Read ↗

WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2<sup>ΔB</sup>-Mediated Telomere ShorteningSemantic proximity Read ↗

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.Semantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.Semantic proximity Read ↗

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structuresSemantic proximity Read ↗

WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1Semantic proximity Read ↗

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNASemantic proximity Read ↗

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicaseSemantic proximity Read ↗

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcriptionSemantic proximity Read ↗

Telomere ResQue and preservation—Roles for the Werner syndrome protein and other RecQ helicasesSemantic proximity Read ↗

Recent Advances in Understanding Werner SyndromeSemantic proximity Read ↗

Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequencesSemantic proximity Read ↗

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