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Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells

9 Mar 2010

Abstract excerpt

Dietary protein malnutrition is manifested as amino acid deprivation of individual cells, which activates an amino acid response (AAR) that alters cellular functions, in part, by regulating transcriptional and posttranscriptional mechanisms. The AAR was activated in HepG2 human hepatoma cells, and the changes in mRNA content were analyzed by microarray expression profiling. The results documented that 1,507 genes...

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PMID: 20215415
DOI: 10.1152/physiolgenomics.00217.2009

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