Article
Analysis of gene expression profile induced by hepatocyte nuclear factor 4alpha in hepatoma cells using an oligonucleotide microarray.
The Journal of biological chemistry - 19 Apr 2002
Naiki Takafumi, Nagaki Masahito, Shidoji Yoshihiro, Kojima Hisanori, Imose Motoaki, Kato Tomohiro, Ohishi Nobuko, Yagi Kunio, Moriwaki Hisataka
Abstract excerpt
Hepatocyte nuclear factor 4alpha (HNF-4alpha), a liver-specific transcription factor, plays a significant role in many liver-specific functions, including lipid, glucose, drug, and ammonia metabolism, and also in embryonal liver development. However, its functions and regulation are not yet clearly understood. In this study, we constructed an adenovirus vector carrying rat HNF-4alpha cDNA and transfected the...
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