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Article

Association of ion-channel genotype and macrocyclic lactone sensitivity traits in Haemonchus contortus.

Molecular and biochemical parasitology - 1 Jun 2010

Beech Robin, Levitt Nancy, Cambos Mathieu, Zhou Shufeng, Forrester Sean G

Abstract excerpt

Resistance to macrocyclic lactones in the strongylid parasite of sheep, Haemonchus contortus, is associated with specific alleles of several genes, including those encoding ligand-gated chloride-channels. While previous functional studies of the ion-channels encoded by these resistant alleles have revealed alterations in ligand binding and response to the anthelmintics, we still do not know how these alleles are...

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PMID: 20211658
DOI: 10.1016/j.molbiopara.2010.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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