Back to search

Article

Sex-biased transcriptional rewiring of neuronal circuits associated with eprinomectin resistance in <i>Haemonchus contortus</i>

2026-07-23

Abstract excerpt

Anthelmintic resistance poses a critical threat to livestock health, with clinical failures of eprinomectin and other macrocyclic lactones documented in the gastrointestinal parasite Haemonchus contortus worldwide. We performed whole-genome Pool-seq of larvae and RNA-seq on adult male and female worms from five phenotypically characterised isolates - two eprinomectin-susceptible and three resistant - from dairy sh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
439544fa-72e7-572b-aa94-1fe42eedfd5a
DOI
10.64898/2026.07.20.739568
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sex-biased transcriptional rewiring of neuronal circuits associated with eprinomectin resistance in <i>Haemonchus contortus</i>DOI 10.64898/2026.07.20.739568
Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematodeSemantic proximity
Genomic landscape of drug response reveals novel mediators of anthelmintic resistanceSemantic proximity
Two novel loci underlie natural differences in <i>Caenorhabditis elegans</i> macrocyclic lactone responsesSemantic proximity
Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, <i>Haemonchus contortus</i>Semantic proximity
Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortusSemantic proximity
Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after 6years of macrocyclic lactone use.Semantic proximity
Genetic variants and increased expression of Parascaris equorum P-glycoprotein-11 in populations with decreased ivermectin susceptibility.Semantic proximity
Characterising anthelmintic resistance against benzimidazoles and macrocyclic lactones in gastrointestinal nematode populations of dairy cattleSemantic proximity
Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta.Semantic proximity
Genome-wide analysis of ivermectin response by <i>Onchocerca volvulus</i> reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivitySemantic proximity
Chromosome-contiguous genome for the Haecon-5 strain of Haemonchus contortus reveals marked genetic variability and enables the discovery of essential gene candidates.Semantic proximity
Mapping resistance-associated anthelmintic interactions in the model nematode <i>Caenorhabditis elegans</i>Semantic proximity
Select a neighboring publication to make it the new centre.