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Article

Genetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus.

Pharmacogenetics and genomics - 1 Feb 2008

de Lourdes Mottier Maria, Prichard Roger K

Abstract excerpt

OBJECTIVES: We have found that in a laboratory strain of the nematode parasite of ruminants, Haemonchus contortus, repeated ivermectin treatment, in vivo in sheep, selected against TTC, coding for Phe, and for TAC, coding for Tyr, at codon 200 in beta-tubulin isotype 1. This 200Tyr single nucleotide polymorphism (SNP) has been associated with benzimidazole anthelmintic resistance. In this study, we investigated...

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Source

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PMID: 18192899
DOI: 10.1097/FPC.0b013e3282f4711d

Genes

GAA
GCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus.PMID 18192899Read ↗

Macrocyclic lactones and their relationship to the SNPs related to benzimidazole resistance.Semantic proximity Read ↗

Haemonchus contortus β-tubulin isotype 1 gene F200Y and F167Y SNPs are both selected by ivermectin and oxfendazole treatments with differing impacts on anthelmintic resistance.Semantic proximity Read ↗

In vitro selection of Haemonchus contortus for benzimidazole resistance reveals a mutation at amino acid 198 of beta-tubulin.Semantic proximity Read ↗

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