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Article

Biosynthetic engineering of natural products for lead optimization and development.

Current opinion in drug discovery & development - 1 Nov 2005

Wilkinson Barrie, Moss Steven J

Abstract excerpt

It is now possible to rapidly and rationally modify, at a genetic level, the machinery responsible for natural product biosynthesis. This provides the opportunity to design new structures and to optimize natural product lead compounds in a way that would be extremely difficult through synthetic chemistry means alone. The technology can also be used to overcome limitations of compound supply, which might otherwise...

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PMID: 16312150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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