The transcription factor FOXL2: at the crossroads of ovarian physiology and pathology.

Abstract excerpt

FOXL2 is a gene encoding a forkhead transcription factor. Its mutations or misregulation have been shown to cause the blepharophimosis-ptosis-epicanthus inversus (BPES) syndrome and more recently have been associated with the development of Ovarian Granulosa Cell Tumors (OGCT). BPES is a genetic disorder involving mild craniofacial abnormalities often associated with premature ovarian failure. OGCTs are endocrine...

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• Blepharophimosis
• Forkhead Box Protein L2
• Forkhead Transcription Factors
• Gene Expression Regulation
• Menopause, Premature