Article
Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer.
Inflammatory bowel diseases - 1 Jan 2011
Laurent Camille, Svrcek Magali, Flejou Jean-François, Chenard Marie-Pierre, Duclos Bernard, Freund Jean-Noël, Reimund Jean-Marie
Abstract excerpt
BACKGROUND: Inflammatory bowel disease (IBD) exposes patients to an increased risk of colorectal cancer (i-CRC) and differences between i-CRC and sporadic colorectal cancer (s-CRC) pathogenesis were reported. In s-CRC, studies indicate abnormalities in the tumor-suppressor gene Cdx2. This study compared CDX2, β-catenin, and TP53 expression in i-CRC, s-CRC, noncancer IBD, and normal control colonic mucosa....
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