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Article

Selective ascorbate toxicity in malignant mesothelioma: a redox Trojan mechanism.

American journal of respiratory cell and molecular biology - 1 Jan 2011

Ranzato Elia, Biffo Stefano, Burlando Bruno

Abstract excerpt

We studied the mechanism of ascorbate toxicity in malignant mesothelioma (MMe) cells. Neutral red uptake showed that ascorbate, but not dehydroascorbate, was highly toxic in the MMe cell lines REN and MM98, and less toxic in immortalized (human mesothelial cells-htert) and primary mesothelial cells. Ascorbate transport inhibitors phloretin, sodium azide, and ouabain did not reduce ascorbate toxicity. Ascorbate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20203294
DOI: 10.1165/rcmb.2009-0340OC

Genes

REN
NOX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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