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Article

Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer.

Cancer research - 15 Jul 2010

Kuiper Caroline, Molenaar Ilona G M, Dachs Gabi U, Currie Margaret J, Sykes Peter H, Vissers Margreet C M

Abstract excerpt

Activation of the transcription factor hypoxia-inducible factor (HIF)-1 allows solid tumors to thrive under conditions of metabolic stress. Because HIF-1 is switched off by hydroxylation reactions that require ascorbate, inadequate intracellular ascorbate levels could contribute to HIF-1 overacti...

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Identifiers

PMID: 20570889
DOI: 10.1158/0008-5472.CAN-10-0263

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BNIP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20570889-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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