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Article

Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53.

Carcinogenesis - 1 Jul 2007

Reynolds Mindy, Zhitkovich Anatoly

Abstract excerpt

Ascorbate (Asc) plays a key role in reductive activation of carcinogenic chromium(VI) in vivo. In addition to much higher rates (t(1/2) = 1 min for 1 mM Asc), its reactions at physiological conditions differ from other reducers by low yields of Cr(V) intermediates. Human cells in culture are severely Asc deficient, which results in distorted metabolism and potentially abnormal responses to Cr(VI). We found that...

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Source

Identifiers

PMID: 17301063
DOI: 10.1093/carcin/bgm031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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