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Article

Sodium Ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake

1 Jan 2007

Abstract excerpt

BACKGROUND: Neuroblastoma (NB) is an extra-cranial solid tumour of childhood. In spite of the good clinical response to first-line therapy, complete eradication of NB cells is rarely achieved. Thus, new therapeutic strategies are needed to eradicate surviving NB cells and prevent relapse. Sodium ascorbate has been recently reported to induce apoptosis of B16 melanoma cells through down-regulation of the...

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PMID: 17760959
DOI: 10.1186/1476-4598-6-55

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