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Article

Involvement of Transcription Factor NR2F2 in Human Trophoblast Differentiation

24 Feb 2010

Abstract excerpt

BACKGROUND: During the in vitro differentiation of human villous cytotrophoblast (CTB) cells to a syncytiotrophoblast (STB) phenotype, mRNA levels for the nuclear hormone receptor NR2F2 (ARP-1, COUP-TFII) increase rapidly, reaching a peak at day 1 of differentiation that is 8.8-fold greater than that in undifferentiated CTB cells. To examine whether NR2F2 is involved in the regulation of villous CTB cell...

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PMID: 20195529
DOI: 10.1371/journal.pone.0009417

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