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A ten markers panel provides a more accurate and complete microsatellite instability analysis in mismatch repair-deficient colorectal tumors

1 Jan 2009

Abstract excerpt

UNLABELLED: Tumour microsatellite instability (MSI) is useful in identifying patients with hereditary non-polyposis colorectal cancer (HNPCC) with defective DNA mismatch repair (MMR) genes. A reference Bethesda panel has limitations resulting from the inclusion of dinucleotide markers, which are less sensitive and specific for detection of tumours with MMR deficiencies. We developed a multiplex PCR assay with...

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Colorectal Cancer Treatments and Studies
Digestive system and related health
Genetic factors in colorectal cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20164541
DOI: 10.3233/cbm-2009-0118

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