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Article

Mutation in TERT separates processivity from anchor-site function.

Nature structural & molecular biology - 1 Aug 2008

Zaug Arthur J, Podell Elaine R, Cech Thomas R

Abstract excerpt

Telomerase shows repeat-addition processivity (RAP): synthesis of multiple telomeric DNA repeats without primer dissociation. Leu14 mutants in the telomerase essential N-terminal domain of Tetrahymena thermophila telomerase reverse transcriptase retain full activity and anchor-site function but l...

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Identifiers

PMID: 18641663
DOI: 10.1038/nsmb.1462
PMCID: PMC2574958

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18641663-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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