Article
Effects of MHC class I alleles on licensing of Ly49A+ NK cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2010
Jonsson A Helena, Yang Liping, Kim Sungjin, Taffner Samantha M, Yokoyama Wayne M
Abstract excerpt
NK cells are innate immune lymphocytes that can react to cells lacking self-MHC class I. However, NK cells that cannot engage self-MHC through an inhibitory receptor are resistant to stimulation through their activation receptors. To become licensed (i.e., functionally competent to be triggered through its activation receptors), an NK cell must engage host MHC class I via a MHC class I-specific inhibitory...
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