Article
Genetic profiles of killer-cell immunoglobulin-like receptors and HLA ligands in Thai blood donors.
Human immunology - 1 Jun 2016
Kitpoka Pimpun, Tammakorn Chutima, Chaisri Suwit, Leelayuwat Chanvit, Mongkolsuk Tasanee, Thammanichanond Duangtawan
Abstract excerpt
Killer-cell immunoglobulin-like receptors (KIRs) play an important role in natural killer (NK) cell regulation. Interaction of KIRs with human leukocyte antigen (HLA) class I molecules can transmit signals to regulate the function of NK cells. In this study, the diversities of KIR genes and their ligands in 500 Thai blood donors were investigated. The coexistence of inhibitory KIRs (iKIR), activating KIRs (aKIR)...
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