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Article

Effects of Particulate Matter on Genomic DNA Methylation Content and <i>iNOS</i> Promoter Methylation

25 Sept 2008

Abstract excerpt

BACKGROUND: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined. OBJECTIVES: We aimed at identifying short- and long-term effects of PM exposure on DNA methylation, a major genomic mechanism of gene expression control, in workers in an electric furnace steel plant with...

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PMID: 19270791
DOI: 10.1289/ehp.11898

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