Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML

27 Feb 2010

Abstract excerpt

DNA hypermethylation of the p15INK4b tumor suppressor gene is commonly observed in acute myeloid leukemia (AML). Repressive histone modifications and their associated binding proteins have been implicated in the regulation of DNA methylation and the transcriptional repression of genes with DNA methylation. We have used high-density chromatin immunoprecipitation-on-chip to determine the histone modifications that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20190193
DOI: 10.1182/blood-2009-07-233858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AMLPMID 20190193Read ↗

Diverse epigenomic mechanisms underpin transcriptional dysregulation in Polycomb-altered acute myeloid leukemiaSemantic proximity Read ↗

Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for LeukemogenesisSemantic proximity Read ↗

Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemiaSemantic proximity Read ↗

UBE2E3 sustains PRC1.1 function and leukemic stemness in acute myeloid leukemiaSemantic proximity Read ↗

KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesisSemantic proximity Read ↗

The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemiaSemantic proximity Read ↗

Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals.Semantic proximity Read ↗

MBD3, a Component of the NuRD Complex, Facilitates Chromatin Alteration and Deposition of Epigenetic MarksSemantic proximity Read ↗

Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemiaSemantic proximity Read ↗

Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice.Semantic proximity Read ↗

Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia.Semantic proximity Read ↗

Expression of <i>ANRIL</i> –Polycomb Complexes– <i>CDKN2A/B/ARF</i> Genes in Breast Tumors: Identification of a Two-Gene ( <i>EZH2/CBX7</i> ) Signature with Independent Prognostic ValueSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.