Article
Human liver expression of CYP2C8: gender, age, and genotype effects.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2010
Naraharisetti Suresh Babu, Lin Yvonne S, Rieder Mark J, Marciante Kristin D, Psaty Bruce M, Thummel Kenneth E, Totah Rheem A
Abstract excerpt
Research investigating CYP2C8 as a drug-metabolizing enzyme has gained momentum over the past few years. CYP2C8 is estimated to oxidatively metabolize approximately 5% of therapeutically prescribed drugs. It is polymorphically expressed, and several single nucleotide polymorphisms have been identified with varying effects on the clearance of CYP2C8 substrates. However, the human liver expression of CYP2C8 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.