Article
Age-dependent posttranslational modifications of voltage-dependent anion channel 1.
Experimental gerontology - 1 Aug 2010
Groebe Karlfried, Klemm-Manns Martina, Schwall Gerhard P, Hübenthal Heiko, Unterluggauer Herrmann, Jansen-Dürr Pidder, Tanguay Robert M, Morrow Geneviève, Schrattenholz André
Abstract excerpt
The accumulation of oxidative damage in mitochondrial proteins, membranes and DNA during ageing is supposed to lead to mitochondrial inactivation, downstream molecular impairments and subsequent decline of biological systems. In a quantitative study investigating the age-related changes of mitoch...
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