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Article

Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder.

Psychiatric genetics - 1 Feb 2010

Silva Hernán, Iturra Patricia, Solari Aldo, Villarroel Juana, Jerez Sonia, Jiménez Marco, Galleguillos Felipe, Bustamante Maria Leonor

Abstract excerpt

BACKGROUND: Disturbances in central serotonin function have been implicated in impulsive and aggressive behavior. A deletion/insertion polymorphism within the 5-HT transporter promoter gene (5-HTTLPR) is thought to be associated with disturbed impulse control, anxiety, and depression. The serotonin transporter (5-HTT) is the primary action site for selective serotonin reuptake inhibitors (SSRIs). Several studies...

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Source

Identifiers

PMID: 20010449
DOI: 10.1097/YPG.0b013e328335125d

Genes

TPH1
HTT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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