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Article

The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.

PloS one - 23 Feb 2010

Bulchand Sarada, Menon Sree Devi, George Simi Elizabeth, Chia William

Abstract excerpt

Drosophila body wall muscles are multinucleated syncytia formed by successive fusions between a founder myoblast and several fusion competent myoblasts. Initial fusion gives rise to a bi/trinucleate precursor followed by more fusion cycles forming a mature muscle. This process requires the functions of various molecules including the transmembrane myoblast attractants Dumbfounded (Duf) and its paralogue Roughest...

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Share to Cell Fusion
Share to Embryo, Nonmammalian
Share to Guanine Nucleotide Exchange Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Muscle Development

Share to Muscle Fibers, Skeletal

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Source

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Identifiers

PMID: 20186342
DOI: 10.1371/journal.pone.0009374
PMCID: PMC2826419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.PMID 20186342Read ↗

Drosophila rolling pebbles: a multidomain protein required for myoblast fusion that recruits D-Titin in response to the myoblast attractant Dumbfounded.Semantic proximity Read ↗

In Drosophila melanogaster, the rolling pebbles isoform 6 (Rols6) is essential for proper Malpighian tubule morphology.Semantic proximity Read ↗

Drosophila dumbfounded: a myoblast attractant essential for fusion.Semantic proximity Read ↗

Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6.Semantic proximity Read ↗

rst and its paralogue kirre act redundantly during embryonic muscle development in Drosophila.Semantic proximity Read ↗

The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts.Semantic proximity Read ↗

The formation of syncytia within the visceral musculature of the Drosophila midgut is dependent on duf, sns and mbc.Semantic proximity Read ↗

Analysis of the cell adhesion molecule sticks-and-stones reveals multiple redundant functional domains, protein-interaction motifs and phosphorylated tyrosines that direct myoblast fusion in Drosophila melanogaster.Semantic proximity Read ↗

kette and blown fuse interact genetically during the second fusion step of myogenesis in Drosophila.Semantic proximity Read ↗

Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila.Semantic proximity Read ↗

rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion.Semantic proximity Read ↗

The mesodermal expression of rolling stone (rost) is essential for myoblast fusion in Drosophila and encodes a potential transmembrane protein.Semantic proximity Read ↗

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