Article
The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.
PloS one - 23 Feb 2010
Bulchand Sarada, Menon Sree Devi, George Simi Elizabeth, Chia William
Abstract excerpt
Drosophila body wall muscles are multinucleated syncytia formed by successive fusions between a founder myoblast and several fusion competent myoblasts. Initial fusion gives rise to a bi/trinucleate precursor followed by more fusion cycles forming a mature muscle. This process requires the functions of various molecules including the transmembrane myoblast attractants Dumbfounded (Duf) and its paralogue Roughest...
Topics
- Animals
- Binding Sites
- Blotting, Western
- Cell Fusion
- Cell Line
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Guanine Nucleotide Exchange Factors
- Immunoprecipitation
- Membrane Proteins
- Muscle Development
- Muscle Fibers, Skeletal
- Muscle Proteins