Article
Primary lateral sclerosis may occur within familial amyotrophic lateral sclerosis pedigrees.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Jan 2010
Praline Julien, Guennoc Anne-Marie, Vourc'h Patrick, De Toffol Bertrand, Corcia Philippe
Abstract excerpt
Primary lateral sclerosis (PLS) is considered to be a specific sporadic motor neuron disorder, but some reports have shown familial history of motor neuron disorders that may comprise PLS cases. Here we report a novel pedigree highlighting an intrafamilial occurrence of PLS and amyotrophic lateral sclerosis (ALS) cases. These observations strengthen the hypothesis that PLS may represent an ALS phenotype with a...
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