Article
Clustering of Neuropsychiatric Disease in First-Degree and Second-Degree Relatives of Patients With Amyotrophic Lateral Sclerosis.
JAMA neurology - 1 Dec 2017
O'Brien Margaret, Burke Tom, Heverin Mark, Vajda Alice, McLaughlin Russell, Gibbons John, Byrne Susan, Pinto-Grau Marta, Elamin Marwa, Pender Niall, Hardiman Orla
Abstract excerpt
Importance: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition primarily involving the motor system. There is increasing epidemiologic evidence of an association between ALS and a wider spectrum of neurodegenerative and neuropsychiatric disorders among family members, including schizophrenia and psychotic illness and suicidal behavior. Objective: To examine the frequency and range of...
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