Article

Dynamic modeling of <i>Streptococcus pneumoniae</i> competence provides regulatory mechanistic insights

2018-04-14

Abstract excerpt

In the human pathogen Streptococcus pneumoniae , the gene regulatory circuit leading to the transient state of competence for natural transformation is based on production of an auto-inducer that activates a positive feedback loop. About one hundred genes are activated in two successive waves linked by a central alternative sigma factor ComX. This mechanism appears to be fundamental to the biological fitness of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 356c9599-b8a0-5f4f-b7f0-1c0804e7588a
DOI: 10.1101/300814

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamic modeling of <i>Streptococcus pneumoniae</i> competence provides regulatory mechanistic insightsDOI 10.1101/300814Read

Dynamic Modeling of Streptococcus pneumoniae Competence Provides Regulatory Mechanistic Insights Into Its Tight Temporal RegulationSemantic proximity Read

ComX is a unique link between multiple quorum sensing outputs and competence in <i>Streptococcus pneumoniae</i>Semantic proximity Read

Development of competence in <i>Streptococcus pneumoniae</i>: pheromone autoinduction and control of quorum sensing by the oligopeptide permeaseSemantic proximity Read

Competence Inhibition by the XrpA Peptide Encoded Within the <i>comX</i> Gene of <i>Streptococcus mutans</i>Semantic proximity Read

Pneumococcal Competence Coordination Relies on a Cell-Contact Sensing MechanismSemantic proximity Read

Expression and maintenance of ComD–ComE, the two‐component signal‐transduction system that controls competence of <i>Streptococcus pneumoniae</i>Semantic proximity Read

Fever-like temperature bursts promote competence development via an HtrA-dependent pathway in <i>Streptococcus pneumoniae</i>Semantic proximity Read

A genome-wide CRISPRi screen reveals a StkP-mediated connection between cell-wall integrity and competence in <i>Streptococcus salivarius</i>Semantic proximity Read

Transformation in Streptococcus pneumoniae: mosaic genes and the regulation of competence.Semantic proximity Read

A hierarchical regulatory cascade defines the temporal window of natural transformation in <i>Staphylococcus aureus</i>Semantic proximity Read

Expression of Streptococcus pneumoniae Bacteriocins Is Induced by Antibiotics via Regulatory Interplay with the Competence SystemSemantic proximity Read

comCDE (Competence) Operon Is Regulated by CcpA in Streptococcus pneumoniae D39Semantic proximity Read