Article
Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects: application to traits related to hypertension.
American journal of human genetics - 1 May 1991
Wilson A F, Elston R C, Tran L D, Siervogel R M
Abstract excerpt
Robust sib-pair linkage analysis can be used as a screening tool in the search for the potential involvement of single-loci, multiple-loci, and pleiotropic effects of single loci underlying phenotypic variation. Four large families were each ascertained through one adult white male with essential hypertension. The robust sib-pair method was used to screen these families for evidence of linkage between 39...
Topics
- Alleles
- Genetic Linkage
- Genetic Markers
- Genetic Techniques
- Humans
- Hypertension
- Phenotype
- Regression Analysis