Article
Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2009
Shi Gang, Gu Chi C, Kraja Aldi T, Arnett Donna K, Myers Richard H, Pankow James S, Hunt Steven C, Rao Dabeeru C
Abstract excerpt
Genome-wide linkage analysis was performed for systolic and diastolic blood pressures in the Hypertension Genetic Epidemiology Network. We investigated the role of gene-age interactions using a recently developed variance components method that incorporates age variation in genetic effects. Substantially improved linkage evidence, in terms of both the number of linkage peaks and their significance levels, was...
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