Article
Identification of hypertension-related QTLs in African American sib pairs.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2002
Kotchen Theodore A, Broeckel Ulrich, Grim Clarence E, Hamet Pavel, Jacob Howard, Kaldunski Mary L, Kotchen Jane Morley, Schork Nicholas J, Tonellato Peter J, Cowley Allen W
Abstract excerpt
To link hypertension-related phenotypes with chromosomal loci, genome scans were performed in 150 African American sib pairs concordant for essential hypertension. Phenotypes included blood pressure, anthropomorphic measurements, and estimates of body fluid compartments as determined by impedance plethysmography. These phenotypes were also measured in 335 normotensive African Americans. Phenotypes with LOD scores...
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