Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome system.

The Journal of cell biology - 22 Feb 2010

Mandal Sudip, Freije William A, Guptan Preeta, Banerjee Utpal

Abstract excerpt

Cell cycle progression is precisely regulated by diverse extrinsic and intrinsic cellular factors. Previous genetic analysis in Drosophila melanogaster has shown that disruption of the mitochondrial electron transport chain activates a G1-S checkpoint as a result of a control of cyclin E by p53....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin E
Share to Electron Transport Complex IV
Share to Eye

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G1 Phase

Share to Proteasome Endopeptidase Complex

Share to Protein Processing, Post-Translational

Share to S Phase

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 20176921
DOI: 10.1083/jcb.200912024
PMCID: PMC2828916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20176921-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome system.PMID 20176921Read ↗

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines.Semantic proximity Read ↗

Loss of dE2F compromises mitochondrial function.Semantic proximity Read ↗

Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.Semantic proximity Read ↗

Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila.Semantic proximity Read ↗

scribble (scrib) knockdown induces tumorigenesis by modulating Drp1-Parkin mediated mitochondrial dynamics in the wing imaginal tissues of DrosophilaSemantic proximity Read ↗

Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic StressSemantic proximity Read ↗

Optogenetic decoupling of ODC inhibition and degradation reveals a requirement of polyamine oscillation for cell cycle progressionSemantic proximity Read ↗

Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis.Semantic proximity Read ↗

Sugar and chromosome stability: clastogenic effects of sugars in vitamin B6-deficient cells.Semantic proximity Read ↗

Maintenance of imaginal disc plasticity and regenerative potential in Drosophila by p53.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.