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Article

Systematic construction of a conceptual minimal model of plasma cholesterol levels based on knockout mouse phenotypes.

Biochimica et biophysica acta - 1 Jun 2010

van de Pas Niek C A, Soffers Ans E M F, Freidig Andreas P, van Ommen Ben, Woutersen Ruud A, Rietjens Ivonne M C M, de Graaf Albert A

Abstract excerpt

Elevated plasma cholesterol, a well-known risk factor for cardiovascular diseases, is the result of the activity of many genes and their encoded proteins in a complex physiological network. We aim to develop a minimal kinetic computational model for predicting plasma cholesterol levels. To define...

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Identifiers

PMID: 20176131
DOI: 10.1016/j.bbalip.2010.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20176131-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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