Article
Systematic construction of a conceptual minimal model of plasma cholesterol levels based on knockout mouse phenotypes.
Biochimica et biophysica acta - 1 Jun 2010
van de Pas Niek C A, Soffers Ans E M F, Freidig Andreas P, van Ommen Ben, Woutersen Ruud A, Rietjens Ivonne M C M, de Graaf Albert A
Abstract excerpt
Elevated plasma cholesterol, a well-known risk factor for cardiovascular diseases, is the result of the activity of many genes and their encoded proteins in a complex physiological network. We aim to develop a minimal kinetic computational model for predicting plasma cholesterol levels. To define the scope of this model, it is essential to discriminate between important and less important processes influencing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.