Article
Genetics of cholesterol and lipoprotein metabolism.
Recent patents on cardiovascular drug discovery - 1 Nov 2007
Samuels Mark E
Abstract excerpt
The goal of drugs is to modulate the activity of particular gene products in order to change the physiological state of an organism from disease to health. Because of the complexity of development and metabolism, it is difficult to extrapolate from in vitro experimental results using purified reagents, to predict the actual change in behavior of an entire biological system in vivo. Metabolic control analysis...
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