Effect of IL-6 -174G/C and -572G/C variants on susceptibility to osteoarthritis in Turkish population.

doi:10.1080/15257770.2022.2107219

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Article

Effect of IL-6 -174G/C and -572G/C variants on susceptibility to osteoarthritis in Turkish population.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2023

Yigit Serbulent, Tekcan Akin, Inanir Ahmet, Nursal Ayse Feyda, Akkanat Songul, Tural Ercan

Abstract excerpt

Osteoarthritis (OA) is a complex disorder characterized by degenerative articular cartilage in which inflammatory mechanisms play a major role in the pathogenesis. Interleukin-6 (IL6), a multifunctional cytokine, can trigger osteoclast differentiation and bone resorption. Our purpose in this study was to evaluate the association of IL-6 -174 G/C (rs1800795) and -572 G/C (rs1800796) variants with the...

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PMID: 35924736
DOI: 10.1080/15257770.2022.2107219

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