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Article

Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population.

Genetics and molecular research : GMR - 1 Jan 2011

Honsawek S, Deepaisarnsakul B, Tanavalee A, Yuktanandana P, Bumrungpanichthaworn P, Malila S, Saetan N

Abstract excerpt

Osteoarthritis is a chronic progressive degenerative joint disease characterized by age-related regressive change in articular cartilage. A single nucleotide polymorphism has been described at position -174 of the interleukin-6 (IL-6) promoter region, leading to three possible genotypes, GG, GC, and CC. We investigated a possible association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai...

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PMID: 21863560
DOI: 10.4238/vol10-3gmr1161

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