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Article

Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.

PloS one - 18 Feb 2010

Utge Siddheshwar J, Soronen Pia, Loukola Anu, Kronholm Erkki, Ollila Hanna M, Pirkola Sami, Porkka-Heiskanen Tarja, Partonen Timo, Paunio Tiina

Abstract excerpt

Disturbances in the circadian pacemaker system are commonly found in individuals with depression and sleep-related problems. We hypothesized that some of the canonical circadian clock genes would be associated with depression accompanied by signs of disturbed sleep, early morning awakening, or da...

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Source

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Identifiers

PMID: 20174623
DOI: 10.1371/journal.pone.0009259
PMCID: PMC2823770

Genes

TIMELESS
PER1
RORA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20174623-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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