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Article

Hypervariable loci in the human gut virome.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2012

Minot Samuel, Grunberg Stephanie, Wu Gary D, Lewis James D, Bushman Frederic D

Abstract excerpt

Genetic variation is critical in microbial immune evasion and drug resistance, but variation has rarely been studied in complex heterogeneous communities such as the human microbiome. To begin to study natural variation, we analyzed DNA viruses present in the lower gastrointestinal tract of 12 human volunteers by determining 48 billion bases of viral DNA sequence. Viral genomes mostly showed low variation, but 51...

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PMID: 22355105
DOI: 10.1073/pnas.1119061109
PMCID: PMC3309749

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