Article
Association of variant alleles of MBL2 gene with vasoocclusive crisis in children with sickle cell anemia.
Blood cells, molecules & diseases - 15 Apr 2010
Mendonça T F, Oliveira M C V C, Vasconcelos L R S, Pereira L M M B, Moura P, Bezerra M A C, Santos M N N, Araújo A S, Cavalcanti M S M
Abstract excerpt
Vasoocclusive crisis (VOC) is the major cause of morbidity and mortality in sickle cell anemia (SCA), which is caused by the occlusion of blood vessels, followed by ischemia or infarct, resulting in progressive damage to organs. However, this clinical manifestation is variable, indicating that this process could be influenced by modifier genes. The gene MBL2 which codes for mannose-binding lectin (MBL) has been...
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