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Article

L-Selectin P213S and Integrin Alpha 2 C807T Genetic Polymorphisms in Pediatric Sickle Cell Disease Patients.

Journal of pediatric hematology/oncology - 1 Nov 2020

Shaheen Iman, Khorshied Mervat, Abdel-Raouf Rasha, Gouda Heba, Kamal Dina, Abulata Nelly, Aboukhalil Reham, Meligy Basant

Abstract excerpt

Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy characterized by increased cellular adhesiveness. Vaso-occlusion (VOC) is the most prevalent disease complication of SCD that could be altered by genetic factors. L-Selectin and integrin alpha 2 (ITGA2) are 2 adhesion molecules linked to vasculopathy and inflammation. The current study aimed at detecting the prevalence of genetic variants of...

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PMID: 32433445
DOI: 10.1097/MPH.0000000000001839

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