Article
The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.
Molecular and cellular biology - 1 May 1991
Jones S, Vignais M L, Broach J R
Abstract excerpt
The product of the CDC25 gene of Saccharomyces cerevisiae, in its capacity as an activator of the RAS/cyclic AMP pathway, is required for initiation of the cell cycle. In this report, we provide an identification of Cdc25p, the product of the CDC25 gene, and evidence that it promotes exchange of guanine nucleotides bound to Ras in vitro. Extracts of strains containing high levels of Cdc25p catalyze both removal...
Topics
- Cell Cycle Proteins
- Cell Membrane
- Fungal Proteins
- Genotype
- Guanosine Diphosphate
- Guanosine Triphosphate
- Kinetics
- Molecular Weight
- Protein Binding
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae