The overexpression of the 3' terminal region of the CDC25 gene of Saccharomyces cerevisiae causes growth inhibition and alteration of purine nucleotides pools.

doi:10.1016/0167-4781(91)90009-b

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Article

The overexpression of the 3' terminal region of the CDC25 gene of Saccharomyces cerevisiae causes growth inhibition and alteration of purine nucleotides pools.

Biochimica et biophysica acta - 13 Jun 1991

Frascotti G, Coccetti P, Vanoni M A, Alberghina L, Martegani E

Abstract excerpt

The CDC25 gene is transcribed at a very low level in S. cerevisiae cells. We have studied the effects of an overexpression of this regulatory gene by cloning either the whole CDC25 open reading frame (pIND25-2 plasmid) or its 3' terminal portion (pIND25-1 plasmid) under the control of the inducib...

Topics

Cell Cycle Proteins
Chromatography, High Pressure Liquid
Cyclic AMP
Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, Regulator
Genes, ras
Open Reading Frames
Phenotype
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Purine Nucleotides

Restriction Mapping

Saccharomyces cerevisiae

Transcription, Genetic

Transformation, Genetic

ras-GRF1

Source

Open in PubMed

Identifiers

PMID: 1647210
DOI: 10.1016/0167-4781(91)90009-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1647210-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The overexpression of the 3' terminal region of the CDC25 gene of Saccharomyces cerevisiae causes growth inhibition and alteration of purine nucleotides pools.PMID 1647210Read ↗

SDC25, a dispensable Ras guanine nucleotide exchange factor of Saccharomyces cerevisiae differs from CDC25 by its regulation.Semantic proximity Read ↗

SDC25, a CDC25-like gene which contains a RAS-activating domain and is a dispensable gene of Saccharomyces cerevisiae.Semantic proximity Read ↗

The Cdc25 protein of Saccharomyces cerevisiae is required for normal glucose transport.Semantic proximity Read ↗

The C-terminal part of the CDC25 gene product plays a key role in signal transduction in the glucose-induced modulation of cAMP level in Saccharomyces cerevisiae.Semantic proximity Read ↗

The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.Semantic proximity Read ↗

Ras-pathway has a dual role in yeast galactose metabolism.Semantic proximity Read ↗

Inactivation of the CDC25 gene product in Saccharomyces cerevisiae leads to a decrease in glycolytic activity which is independent of cAMP levels.Semantic proximity Read ↗

A role for the noncatalytic N terminus in the function of Cdc25, a Saccharomyces cerevisiae Ras-guanine nucleotide exchange factor.Semantic proximity Read ↗

New roles for CDC25 in growth control, galactose regulation and cellular differentiation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Interaction between the Saccharomyces cerevisiae CDC25 gene product and mammalian ras.Semantic proximity Read ↗

A Candida albicans homolog of CDC25 is functional in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutagenic alteration of the distal switch II region of RAS blocks CDC25-dependent signaling functions.Semantic proximity Read ↗

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