Article
Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.
The EMBO journal - 1 Jun 1992
Martegani E, Vanoni M, Zippel R, Coccetti P, Brambilla R, Ferrari C, Sturani E, Alberghina L
Abstract excerpt
In the yeast Saccharomyces cerevisiae genetic and biochemical evidence indicates that the product of the CDC25 gene activates the RAS/adenylyl cyclase/protein kinase A pathway by acting as a guanine nucleotide protein. Here we report the isolation of a mouse brain cDNA homologous to CDC25. The mo...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Cell Cycle Proteins
- Cloning, Molecular
- Cyclic AMP
- DNA
- DNA, Fungal
- Enzyme Activation
- Escherichia coli
- Fungal Proteins
- GTP-Binding Proteins
- Gene Expression Regulation, Fungal